Nolicin - indications for use and important features of the drug. Common diseases of the kidneys and urinary system

In this article, you can read the instructions for use medicinal product Nolicin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of the antibiotic Nolicin in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Nolicin in the presence of existing structural analogues. Use for the treatment of cystitis, urethritis, pyelonephritis in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Nolicin- an antimicrobial drug of the group of fluoroquinolones with a wide spectrum of action.

It has a bactericidal effect. Affects the bacterial enzyme DNA-gyrase, which provides supercoiling and, thus, the stability of bacterial DNA. Destabilization of the DNA chain leads to the death of bacteria. It has a wide spectrum of antibacterial action.

Staphylococcus aureus (including strains of Staphylococcus spp. resistant to methicillin), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp., Enterobacter spp., Hafhia alvei, Proteus spp. are sensitive to the drug. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp., Yersinia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp., Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp., Legionella spp.

Different sensitivity to the drug have: Enterococcus faecalis, Streptococcus spp. (Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum.

The duration of the antimicrobial action is about 12 hours.

Compound

Norfloxacin + excipients.

Pharmacokinetics

After oral administration, Nolicin is rapidly but not completely (20-40%) absorbed from the gastrointestinal tract. Eating slows down the absorption of the drug. It penetrates well into organs and tissues (kidney parenchyma, ovaries, seminiferous tubule fluid, prostate gland, uterus, organs abdominal cavity and small pelvis, bile, mother's milk). Penetrates through the blood-brain barrier (BBB) ​​and the placental barrier. It is metabolized to a small extent in the liver. It is excreted by the kidneys, by glomerular filtration and tubular secretion.

Indications

Infectious and inflammatory diseases caused by pathogens sensitive to the drug:

• acute and chronic infectious diseases urinary tract(urethritis, cystitis, pyelonephritis);
• genital infections (cervicitis, endometritis, chronic bacterial prostatitis);
• gonorrhea uncomplicated;
• bacterial gastroenteritis (salmonellosis, shigellosis);
• prevention of recurrence of urinary tract infections;
• prevention of sepsis in patients with neutropenia;
• prevention of traveler's diarrhea.

Release form

Film-coated tablets 400 mg.

Instructions for use and dosing regimen

Inside, on an empty stomach (at least 1 hour before or 2 hours after a meal) and drink plenty of fluids.

In chronic bacterial prostatitis - 400 mg 2 times a day. for 4-6 weeks or more.

With uncomplicated gonorrhea - once at a dose of 800-1200 mg or 400 mg 2 times a day for 3-7 days.

With bacterial gastroenteritis (shigellosis, salmonellosis) - 400 mg 2 times a day for 5 days.

For the prevention of travelers' diarrhea, it is recommended to take 400 mg per day 1 day before departure, during the entire trip and 2 days after it ends (no more than 21 days).

For the prevention of sepsis in neutropenia - 400 mg 2 times a day for 8 weeks.

In acute uncomplicated cystitis - 400 mg 2 times a day for 3-5 days.

For the prevention of recurrent uncomplicated urinary tract infections with frequent exacerbations (more than 3 episodes per year or more than 2 within six months) - 200 mg once a night for a long time (from 6 months to several years).

Side effect

• loss of appetite;
• bitterness in the mouth;
• nausea, vomiting;
• abdominal pain;
• diarrhea;
• pseudomembranous enterocolitis (with prolonged use);
• glomerulonephritis;
• polyuria;
• urethral bleeding;
• increase in urea and creatinine in blood plasma;
• headache;
• dizziness;
• fainting;
• insomnia;
• hallucinations;
• fatigue;
• drowsiness;
• anxiety;
• irritability;
• feeling of fear;
• depression;
• noise in ears;
• tachycardia;
• arrhythmias;
• decrease in blood pressure;
• vasculitis;
• tendon ruptures (usually in combination with contributing factors);
• eosinophilia, leukopenia, decreased hematocrit;
• rash;
• skin itching;
• hives;
• swelling;
• malignant exudative erythema (Stevens-Johnson syndrome);
• candidiasis.

Contraindications

• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• lactation ( breast-feeding);
• children's and adolescence up to 18 years;
• hypersensitivity to norfloxacin and other drugs of the fluoroquinolone group.

Use during pregnancy and lactation

The safety of use during pregnancy and lactation (breastfeeding) has not been studied.

Nolicin should be prescribed during pregnancy only for health reasons, when the intended benefit to the mother outweighs the potential risk to the fetus.

If necessary, the appointment of the drug during lactation should stop breastfeeding.

special instructions

During the period of treatment, Nolicinombolic patients should receive a sufficient amount of fluid (under the control of diuresis).

During therapy, an increase in the prothrombin index is possible (during surgical interventions, the state of the blood coagulation system should be monitored).

During treatment with norfloxacin, direct sunlight should be avoided.

With the appearance of pain in the tendons or at the first signs of tendovaginitis, it is necessary to stop the drug. During therapy with norfloxacin, it is recommended to avoid excessive physical exertion.

If you have an allergic reaction to acetylsalicylic acid azo dye E 110 (dispersed yellow dye, E110), can cause a hypersensitivity reaction, up to bronchospasm.

Influence on the ability to drive vehicles and control mechanisms

Care must be taken when driving a car and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions (especially with the simultaneous use of ethanol (alcohol)).

drug interaction

With the simultaneous use of Nolicin and theophylline, the concentration of theophylline in the blood plasma should be monitored and its dose adjusted, because. norfloxacin reduces the clearance of theophylline by 25%, and the development of corresponding undesirable side effects can be observed.

Nolicin reduces the effect of nitrofurans.

Norfloxacin can enhance the therapeutic effect of cyclosporine and warfarin, in some cases, when using norfloxacin with cyclosporine, an increase in serum creatinine concentration was observed, therefore, in such patients, control of this indicator is necessary.

The simultaneous use of norfloxacin and antacids containing aluminum or magnesium hydroxide, as well as preparations containing iron, zinc, sucralfate, reduces the absorption of norfloxacin (the interval between their intake should be at least 2 hours).

Simultaneous use with drugs that reduce the convulsive threshold may lead to the development of epileptiform seizures.

Simultaneous use with glucocorticosteroids (GCS) may increase the risk of tendonitis or cases of tendon rupture.

Nolicin can enhance the therapeutic effect of hypoglycemic drugs (sulfonylurea derivatives).

Simultaneous administration of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with simultaneous administration with barbiturates and other drugs for general anesthesia, heart rate, blood pressure and ECG parameters should be monitored.

Analogues of the drug Nolicin

Structural analogues for the active substance:

• Lokson-400;
• Norbactin;
• Norilet;
• Normax;
• Noroxin;
• Norfacin;
• Norfloxacin;
• Renor;
• Sofazin;
• Chibroxin;
• Youtibid.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Antimicrobials are indicated for the treatment of urogenital infections. Nolicin from the pharmacological group of quinolones effectively fights the reproduction of pathogenic bacteria in the body. The medicine helps with diseases genitourinary system. Nolicin instructions for use for e and urethritis recommends that patients take it as prescribed by a doctor.

The active ingredient is norfloxacin. The drug belongs to pharmacological group 2nd generation fluoroquinolones. Norfloxacin is a metabolite of pefloxacin, from which it differs by the absence of a methyl group at the piperazine core.

The active substance has an antibacterial, bactericidal effect. In addition to the active ingredient, the composition contains additional ingredients.

How it works

The drug Nolicin is available in tablets. The dosage of the active substance is 400 mg. The antibiotic agent has a cumulative effect, it is not excreted from the human body for a long time. In men, the remains are stored in the prostate gland, bladder, intestines, kidneys, in women - in the organs of the genitourinary system.

There is no form of release in capsules or suppositories, the antibiotic is sold only in tablet form. For therapeutic course 1 package is enough. Since the drug has a cumulative effect, the effect can occur a few days after the end of antibiotic therapy.

Nolicin has a wide spectrum of action, is resistant to many microorganisms that are not amenable to treatment with other drugs from the group of antibiotics. However, it doesn't work medicine with streptococci and anaerobic bacteria.

Basically, antimicrobial treatment is prescribed for infections caused by Escherichia or dysentery coli, Enterobacter, Mycoplasma, Klebsiella, Chlamydia, Salmonella, Vibrio cholerae, gonococci or staphylococci.

Release forms, prices

The drug is available only in tablets, there are no other forms. 1 tablet contains 40 mg of norfloxacin. There are 10 tablets in a blister. In one carton 1-2 contour cells. The price of the drug varies depending on the size of the pack and ranges from 110 to 300 rubles.

The tablets are film-coated. There is a notch on one side. The color is orange, there may be small inclusions on the surface. The tablet can be divided into two equal parts.

Speed ​​and duration

The speed of the body's reaction to drugs is individual. How long does it take for the pill to work? It depends on the person's health, diagnosis, and intake before or after meals. The drug quickly enters the bloodstream, the maximum concentration of the active substance is observed after 1-2 hours.

The action time lasts for 10-12 hours. The effectiveness of the active substance is reduced if the drug is taken with fatty foods, during meals or immediately after it. It is recommended to take the remedy 1-2 hours after breakfast.

Absorption is fast, sufficient medicinal dose antibiotic is observed already on the second day of the treatment course. More than 15% of the active substance binds to plasma proteins. After how much is excreted from the body - a day after taking the first pill, 32% of the drug is excreted from the body.

The half-life is 3-4 hours. Basically, the drug is excreted in the urine and bile, a small part is excreted by the intestines. In patients with impaired renal function, there may be some change in the pharmacokinetic parameters of norfloxacin.

Indications for use

Antibiotic therapy is indicated for complicated forms of infection. Nolicin copes with diseases in which other drugs have shown little effectiveness. The drug is used even for the treatment of chronic diseases. Let's list what this antibiotic helps with.

The drug in a reduced dosage is often used not only for treatment, but also for prevention. infectious diseases. Most often, the medication is prescribed for diseases of the genitourinary system, but it also copes with some disorders of the gastrointestinal tract.

Course of treatment and dosage

The drug is indicated in prophylactic doses of no more than 800 mg of norfloxacin per day (2 tablets). The drug is taken in the morning and evening 2 hours after a meal or one hour before a meal. Prophylactic reception can last 1.5-2 months.

To treat diarrhea in travelers, the first tablet should be taken 1-2 days before the intended departure. Daily dose- 400 mg (1 tablet). The course of treatment should be continued throughout the journey and for another 2-3 days after arrival. Course duration - up to 3 weeks.

To prevent the recurrence of infectious diseases in an uncomplicated form, half a tablet is prescribed. You need to drink it before going to bed, at night. A small dose of 200 mg of norfloxacin helps to stop the activity of pathogenic microorganisms. The duration of such prophylaxis can be from 6 months to 2-3 years.

In case of impaired renal function, dosage adjustment is required. With kidney problems and the patient is on hemodialysis, it is better to take no more than 200 mg of the active substance per day. It is acceptable to use 400 mg of norfloxacin divided into 2 doses (morning and evening).

Self-medication is strictly prohibited. Before starting a preventive course or aggressive drug therapy, consult your doctor. Antibiotics have many contraindications and side effects.

With cystitis

Tablets are taken orally, if necessary, drink a small dose of the drug Nolicin can be divided into two parts. Grinding the drug is prohibited. For infectious diseases of the genitourinary system, the appointment should be scheduled 1 hour before or 2 hours after a meal.

How to take nolicin for cystitis:

1. Preventive treatment. It is prescribed individually depending on the severity of the disease. The daily dose is 400 mg. In uncomplicated forms, it can be reduced by 2 times, in severe cases - increased to 800 mg of norfloxacin.
2. Treatment of cystitis. With an exacerbation of the disease and the primary manifestation, a course of 1 tablet is prescribed 2 times a day. The duration of therapy is from 3 to 8 weeks.

The duration and dosage are also determined individually, depending on the type of bacteria that provoked the disease or exacerbation. During therapy with Nolicin, you should drink enough water to speed up the excretion of the antibiotic in the urine.

With prostatitis

The drug can be prescribed for both acute and chronic forms of the disease. Prevention is carried out by taking small doses - 400-800 mg each. With the initial manifestation and exacerbation of the disease, the dosage of the active substance can be increased to 800 mg. In such cases, the functionality of the prostate is restored quickly.

The course of treatment is selected individually depending on the age of the patient and the presence of contraindications. Most often, antibiotic therapy lasts from 4 to 6 weeks. The prophylactic course can last 6-12 months.

When e

Urethritis responds quickly to treatment. For problems with the urinary tract, Nolicin shows high efficiency. In uncomplicated forms, it is enough to take 1 tablet 2 times a day for 3-5 days.

In infectious diseases that turn into complicated urethritis, the duration of therapy is 2 weeks. In the chronic type, the dosage may be reduced, and treatment continues for 3-4 months.

Side effects

The drug Nolicin has side effects. Undesirable negative effects often occur due to incorrect dosage of the active substance. To avoid side effects, it is better to consult a doctor before taking it.

Side effects:

1. From the gastrointestinal tract: spastic pain in the abdominal region, a violation of the digestive process.
2. From the hepatobiliary system: anorexia, increased activity of liver enzymes.
3. Pseudomembranous colitis, pancreatitis, hepatitis, jaundice.
4. From the side of the central nervous system: insomnia and other sleep disorders, headache, development of depression, irritability and anxiety, aggressiveness and irritability, disorientation in space, tinnitus, dizziness, hallucinations.
5. In rare cases: paresthesia, polyneuropathy, convulsions, tremor.
6. From the circulatory system: hemolytic anemia, agranulocytosis, eosinophilia, neutropenia, thrombocytopenia, leukopenia.
7. From the side of the cardiovascular system: development of arterial hypotension, ventricular arrhythmia, prolongation of the QT interval.
8. Allergic manifestations: bronchial asthma, skin rashes, urticaria, vasculitis, state of shock, angioedema, Lyell's syndrome, Stevens-Johnson syndrome, photosensitivity.

Sometimes taking the drug negatively affects the functioning of muscles and joints, there is a risk of arthritis, exacerbation of myasthenia gravis, tendinitis, interstitial nephritis. Rarely, there is an increase in the level of creatinine kinase, vaginal candidiasis (thrush).

When using a large amount of Nolicin, overdose symptoms may occur. After the pills, work is disrupted digestive system, confusion, fatigue and convulsions appear. In this case, symptomatic treatment is carried out.

Can be taken at home Activated carbon or other enterosorbents. In severe forms, gastric lavage, hemodialysis are indicated. To normalize the condition and promptly remove the products that provoked poisoning, it is recommended to use a large number of water.

Compatibility with other drugs and alcohol

When using the drug, it is worth considering its drug compatibility with other medicines. Some drugs tend to neutralize the action of Nolicin or enhance it.

Compatibility with other drugs:

1. Probenecid. It does not greatly affect the concentration of norfloxacin in the blood, but slows down its excretion with urine.
2. Drugs metabolized with the participation of the CYP1A2 isoenzyme. This category of drugs includes: clozapine, theophylline, tizadine, ropinirole, caffeine. The simultaneous use of these drugs with Nolicin increases the level of caffeine in the blood.
3. Cyclosporine. Simultaneous use increases the concentration of cyclosporine.
4. Warfarin and its derivatives. The use of Nolicin and warfarin provokes an increase in the prothrombin action of the latter.
5. Antacids. The bioavailability of the original agent is reduced. Also occurs when didanosine, sucralfate and dairy products are taken concomitantly. It is recommended to maintain a break between taking 1-2 hours.
6. Some minerals. Simultaneous reception with magnesium, calcium, zinc, bismuth, iron and aluminum forms chelate complexes. It is also better to pause between doses of 2-3 hours.
7. Corticosteroids. You can provoke a rupture of the tendons and the development of tendonitis.
8. Antidiabetic agents. The doctor will prescribe constant monitoring of blood sugar levels if treatment with Nolicin is strictly necessary.
9. Nitrofurantoin. Simultaneous use reduces the effectiveness of both drugs.
10. Non-steroidal anti-inflammatory drugs. There is a risk of seizures. The same reaction can occur when using fenbufen.

Antibiotic therapy with Nolicin is not combined with alcohol. At the time of treatment, it is recommended to give up alcoholic beverages, even in small doses. The patient may feel tired, drowsy and lose strength, there is a risk of severe allergic reactions when combined with alcohol.

Contraindications

The drug is prescribed to patients who have reached the age of 18 years. In pediatric practice drug therapy Nolicin is not used. Also, you can not prescribe an antibiotic to women during pregnancy and breastfeeding.

Among the contraindications are observed:

• individual intolerance to components from the composition;
• deficiency of glucose-6-phosphate dehydrogenase;
• childhood;
• the period of pregnancy and lactation in women;
• hypersensitivity to acetylsalicylic acid.

With intolerance to aspirin, the use is possible only in a reduced dosage and under the supervision of a physician. With atherosclerosis, epilepsy and other diseases of the central nervous system, renal and hepatic insufficiency, the drug is prescribed with caution.

During the period of therapy, prolonged exposure to the sun should be avoided. It is also recommended to refuse to drive vehicles, not to engage in work associated with increased responsibility.

Analogues

Antibiotic therapy can often be replaced with diuretic treatment. Among relative analogues, is known, however, with bacterial diseases severe, it is ineffective. Structural substitutes with an identical active substance in the composition are popular. You can get acquainted with the best analogues in the table.

Analogues in cost are approximately in the same category. Replacement of the original with a generic drug sold in pharmacies at a lower price must be approved by the attending physician. Despite the similar composition and mode of action of the drugs, it is recommended to carefully read the instructions before use.

Video

Watch this video about the effect of the drug on the body and the rules for taking it.

Instructions for use refers Nolicin to drugs from the group of fluorinated quinolones. A modern antibiotic exhibits a powerful bactericidal effect against a wide range of pathogenic microorganisms. The drug is used in various fields of medicine for the treatment of inflammatory and infectious processes, the pathogens of which are sensitive to the active substance of the drug.

Tablets Nolicin - description of the drug

The active substance of Nolicin is norfloxacin. The mechanism of its action is aimed at inhibiting the synthesis of proteins in the microbial cell, which leads to the destruction of DNA chains and the death of the microorganism. The antimicrobial drug exhibits a bactericidal effect against many pathogens of infectious diseases:

• coli and dysentery;
• enterobacteria;
• shigella;
• salmonella;
• mycoplasmas;
• chlamydia, gonococci;
• Klebsiella;
• cholera vibrio;
• neisseria, etc.

At the same time, anaerobic bacteria and streptococci are insensitive to the action of norfloxacin.

After oral administration, the drug is rapidly absorbed, penetrates well into all organs and tissues, passes through the placental and blood-brain barrier. The maximum concentration of the active substance in the blood is reached within 1-2 hours. Eating may slow down the absorption of the active substance. The antimicrobial effect of Nolicin persists for 12 hours after taking the pill. It is excreted from the body mainly by the kidneys, together with urine.

Nolicin is produced in the only dosage form- in the form of round, biconvex, orange film-coated tablets. Each tablet contains 400 mg of norfloxacin and a number of auxiliary components. Nolicin 400 mg is packaged in blisters of 10 tablets and placed in cardboard boxes. The pack contains 1 or 2 blisters with tablets.

Indications for use

Nolicin tablets are prescribed for a wide range of infectious and inflammatory pathologies:

• acute and chronic diseases of the urinary tract (pyelonephritis, urethritis, cystitis);
• genital infections (chronic bacterial prostatitis, cervicitis, endometritis, uncomplicated forms of gonorrhea);
• sharp intestinal infections(salmonellosis, dysentery).

The drug is included in the complex treatment of bacterial gastroenteritis. Prophylactically, Nolicin is taken to prevent traveler's diarrhea or septic complications in neutropenic individuals.

Instructions for use

In what dosage and how much to drink Nolicin is determined by the attending physician, taking into account the patient's condition, the nature of the disease and possible contraindications. The instruction to the drug prescribes to take the tablets as a whole 1 hour before meals or 2 hours after the next meal, drinking plenty of water with them.

The standard average daily dose is 800 mg, that is, 2 tablets of 400 mg in two divided doses (morning and evening). The time interval between taking the next dose should be 12 hours. This dosage is followed in the treatment of bacterial prostatitis, uncomplicated cystitis, gastroenteritis and for the prevention of sepsis.

In the treatment of gonorrhea (uncomplicated), you can drink a "shock" dose of the drug once - 800-1200 mg or take tablets according to the standard scheme (1 tablet twice a day) for 3-7 days.

In order to prevent "traveler's diarrhea", you should take 1 tablet of Nolicin the day before departure and then follow this regimen for the entire duration of the trip (but not more than 3 weeks).

Patients with impaired renal function and kidney failure a single dose of the drug is reduced by half with a double dose or it is recommended to take the full dose (400 mg) once a day. In persons with functional impairment of the kidneys, it is not necessary to change the dosage regimen of the drug.

How much to take Nolicin? The duration of treatment depends on the nature of the disease. On average, the course of treatment takes 1-2 weeks, if necessary, the doctor can extend it. The longest intake of the drug is recommended for the prevention of recurrence of infectious diseases of the genitourinary tract. If exacerbations occur more than 3 times a year, Nolacin is taken 1/2 tablet at night for 3-6 months. In order to prevent sepsis, the drug is prescribed for up to 2 months. During treatment chronic prostatitis tablets are taken for 1-1.5 months.

Treatment of cystitis with Nolicin takes an average of 3-5 days. With an uncomplicated course of the disease, this period is enough to achieve a therapeutic effect. In addition, in such a short time, the toxicity of the drug practically does not manifest itself, therefore, adverse reactions do not develop. Reviews of the use of Nolicin for cystitis suggest that the drug quickly copes with the symptoms of the disease, stops the inflammatory process, relieves pain and pain during urination.

The same period (up to 5 days) is allotted for the use of the drug in acute manifestations of bacterial gastroenteritis. To eliminate the symptoms of proctitis, cervicitis, urethritis, a single dose of Nolicin at a dosage of 400 mg is sufficient.

Contraindications

All admission restrictions antibacterial agent can be divided into absolute and relative.

Absolute contraindications include:

• individual intolerance to norfloxacin and other agents from the group of fluoroquinolones;
• periods of gestation and lactation;
• congenital deficiency of a special enzyme (glucose-6-phosphate dehydrogenase);
• age up to 18 years.

Among the relative contraindications, the presence of which does not imply a complete ban of the drug, such conditions as a tendency to allergic reactions to acetylsalicylic acid, atherosclerotic changes in the vessels of the brain and cerebrovascular accidents, renal and hepatic insufficiency, as well as manifestations of the epileptic syndrome (including anamnesis). Such conditions require a balanced approach to treatment with Nolicin. It is prescribed with extreme caution, in individual dosages and under the supervision of a physician.

Nolicin during pregnancy and during breastfeeding is prohibited for use. During these periods, the drug should be prescribed only for vital signs, and only in cases where the expected benefit to the mother outweighs the potential risk. negative consequences for the fetus. If there is a need for treatment during lactation, breastfeeding is stopped, the baby is transferred to artificial mixtures.

Adverse reactions

During treatment with an antimicrobial agent, undesirable symptoms from various body systems may appear. Most often, there are adverse reactions from the digestive system, which are expressed:

• nausea, vomiting;
• lack of appetite;
• a feeling of bitterness in the mouth;
• the appearance of pain in epistragia;
• symptoms of pseudomembranous enterocolitis;
• increased activity of transaminases;
• changes in blood parameters and an increase in its coagulability.

Common side effects include the urinary system. There is an increase in the volume of urine (polyuria), cutting during urination, the release of salts, protein or blood in the urine, manifestations of glomerulonephritis (inflammation of the kidney tissue).

From the side of the nervous system, taking the drug provokes headaches, insomnia, a feeling of fatigue, increased anxiety, unreasonable fears, dizziness, tinnitus, irritability or depression. In severe cases, severe reactions are possible - convulsions, falling blood pressure, fainting, hallucinations.

Side effects that are much less common are allergic reactions, disorders heart rate(arrhythmias, tachycardias), symptoms of vasculitis, inflammation and rupture of the tendons, joint pain, candidiasis, or the development of malignant erythema.

If any of the above symptoms appear, the drug should be discontinued and a doctor should be consulted about the further course of treatment and the possibility of replacing the drug.

During treatment with Nolicin, the patient is advised to drink more fluids and control the course of diuresis. Before prescribing the drug, a preliminary determination of the sensitivity of microorganisms to the active substance is necessary, since some pathogens are resistant to norfloxacin. In this case, the effect of the drug will not be.

When treating pyelonephritis, it is recommended to combine Nolicin with herbal medicines (for example, Kanefron). You can not prescribe an antibiotic simultaneously with antihypertensive drugs in order to avoid a sharp drop in blood pressure. When used together with antacids that reduce the acidity of gastric juice, a time interval of 2 hours should be observed between taking the drugs.

Good to know

Treatment with Nolicin should not be combined with alcohol intake. Ethyl alcohol in combination with an antibiotic can provoke severe allergic reactions or lead to a drop in performance due to feelings of extreme fatigue, dizziness, loss of strength, and drowsiness.

Analogues

If necessary, Nolicin can be replaced by analogues containing the same active substance. This list includes drugs such as Norbactin, Normaks, Sofazin, Renor, Yutibid.

The decision to replace is entirely the prerogative of the attending physician; you should not select analogues on your own, as this can lead to undesirable complications and unpredictable consequences.

The cost of Nolicin

The price of an antimicrobial agent in pharmacies depends on the number of tablets in the package. Nolicin 400mg (10pcs) costs from 160 rubles, a pack of 20 tablets is sold at an average price of 300 to 350 rubles.

Nolicin is an effective antibacterial agent.

The drug is often used in the complex treatment of infectious and inflammatory diseases of the urinary organs.

There are positive reviews of patients who took this medicine.

They indicate that the drug has many benefits. Experts also speak well of Nolitsin.

Description of the drug and instructions for use

The drug contains the active substance -. The composition also contains auxiliary components.

Refers to antibacterial drugs that act on many pathogens. Has a wide range of effects.

This remedy is considered a very strong antibiotic. The drug has a large list of restrictions for use and adverse reactions. Therefore, Nolicin can only be used for medical purposes. It is usually used when there is no effect from the use of less toxic drugs.

Alexander Nikolaevich, urologist

Nolicin is a popular and effective antibiotic used for a disease such as pyelonephritis. I agree with the opinion that the drug is powerful in action, so its use can be justified by the attending physician only after receiving the result. In the acute form of the disease, it can be prescribed immediately.

Ekaterina Afanasievna, nephrologist

Nolicin is a well-known antibiotic of the fluoroquinalone group. The drug is used to treat infectious diseases of the urinary organs. The effect of the tablets is observed in a day. I often use Nolicin in my urological practice.

Elena Alexandrovna

I can determine the advantages of the medicine: fast effectiveness, inexpensive price. Among the disadvantages - in some cases there is no desired result, since bacteria develop resistance to active substances Nolicina.

Anatoly Sergeevich, urologist

The antibiotic is powerful and effective, so it is not allowed to use it without the appointment of a specialist. I prescribe only for uncomplicated cystitis.

Oleg Pavlovich

Patient opinion

Most patients took Nolicin for urological problems. There are positive reviews about taking the drug for cystitis and urethritis.

Taken for cystitis

Patient reviews indicate that the medicine is good for cystitis.

I want to note the high efficiency of Nolicin - the tablets helped after one day, the pain in the lower abdomen and during urination noticeably decreased, and the cramps stopped. The advantage of the tool is also its relatively inexpensive cost - up to two hundred rubles.

Ruslana, 45 years old

With an exacerbation of cystitis, a familiar urologist Nolitsin prescribed me. Indeed, the medicine helps to quickly get rid of the manifestations of the disease. However, in the course of treatment, I observed unpleasant symptoms on the part of digestion - nausea, there was a slight diarrhea, there were pains in the abdomen.
Anastasia, 37 years old

The drug was advised to me by a friend who was prescribed these pills for inflammation of the urea. I drank them according to the instructions for four days, but did not feel any relief. The tool did not help me at all, and even caused some side reactions. After consulting a doctor and switching to another drug, the state of health improved significantly.

Valentina, 40 years old

Since childhood, cystitis often worsens. I took various remedies, but they help only for a short time. As soon as the weather changes, a cold sets in, I immediately get sick again. The last time I was prescribed Nolicin was for cystitis caused by some other bacterium. I have been taking the pills for seven days now. I follow the dosage and mode of application, but I drink a little liquid. Adverse reactions began to appear in the form of muscle pain and fatigue. For now, I will endure, because the signs of cystitis are noticeably disappearing.

Alexandra, 36 years old

For the fourth day I have been running to the toilet in a small way every five minutes, and very little urine is excreted. There was a pain, I can not empty normally bladder so I went to the doctor. Appointed in the complex Kanefron and Nolitsin. The antibiotic helped already in the evening. I hope that with such a pace, recovery will come quickly.

Lyudmila, 30 years old

Not good good drug. I used it twice - and a terrible allergy began. The skin on the legs and arms was swollen and covered with rashes. I don't want to take these pills anymore.

Nikolay, 38 years old

And the drug helped me quickly. Signs of cystitis disappeared. I drank it for three days, and did not find any side effects. Recently, the disease worsened again - and I again started drinking Nolicin. However, this time I took the pills for a day longer. There were signs of candidiasis. Therefore, it is better not to exceed the course of treatment and dosage. It is advisable not to take such strong antibiotics without medical prescription.

Oksana, 40 years old

Used for urethritis

Some patients have been treated with Nolicin urethritis. They note that the drug quickly eliminates the signs of the disease. There are also negative reviews about the medicine.

I drank a course of Nolicin for urethritis a few days ago. Relief came only for a few days. The symptoms returned again. Tomorrow I'll go for an examination. Nolicin does not always help and not for everyone.

Lisa, 26 years old

I took pills for frequent urination, because I went to the toilet up to ten times in one hour. The side effect was low blood pressure. But the drug really helped, and the pressure soon became normal. My doctor said that for the best effectiveness of therapy, you should not drink alcohol and be less under the sun. If you follow all the recommendations, then there will be no side effects.

Ruslan, 50 years old

Used in treatment chronic urethritis. The tool is very effective and eliminates the signs of the disease, including frequent urge to urinate, soreness. Among the advantages of the drug is the low price.

Olga, 49 years old

Nolicin was prescribed to my grandmother for urethritis. The medicine removed the inflammatory process in a few days. side effects did not have. Now my grandmother constantly stocks up on these pills.

Ekaterina, 34 years old

Of all the drugs that were prescribed to me for exacerbations of urethritis, only Nolicin came to my aid. The tool is very good, inexpensive and high quality. Helps in complex treatment. I tolerated the pills well. side effects didn't watch.

Maria, 43 years old

After taking it, I had a terrible allergy. I took the pills earlier six months before, then there was no such reaction. In addition, there is an increase in heart rate and chills after using the medicine.

Gulnara, 52 years old

For other urological pathologies

Many patients prefer this drug for its effectiveness and affordable price, but there are also adverse reactions.

The drug is used to treat urinary tract infections, it can also be used for diarrhea during travel. It has contraindications and side effects. It helps well, but you need to drink plenty of fluids during the reception, monitor diuresis and read the instructions in detail.

Katya, 26 years old

I suffer from chronic diseases of the urinary tract and doctors prescribe mountains of expensive medicines. I decided to try Nolicin, it has the same active ingredient, but it is much cheaper. You need to drink in a course and not on an empty stomach, when there was a pregnant woman, the treatment was interrupted. Overall, not bad.

Anastasia, 33 years old

Thus, Nolicin is effective antibiotic for the treatment of urethritis and cystitis. The medicine helps quickly for patient feedback.

However, side effects sometimes occur. There have been cases of lack of effectiveness from taking the medicine. Among the advantages of the drug is a relatively low cost.

Instruction

Nolicin is a drug aimed at destroying microbes in the urinary tract and for the prevention of diarrhea. Tablets have a wide spectrum of action and are effective in bacterial lesions of the pelvic organs.

Nolicin is a drug aimed at destroying microbes in the urinary tract and for the prevention of diarrhea.

Latin name

Compound

The active substance is norfloxacin. 1 tablet contains 400 mg of the component. Added a number of auxiliary substances:

• povidone:
• magnesium stearate, etc.

Action

The components in the complex act on pathogens, blocking their activity and reproduction. As a result, after the course of treatment, the patient's condition improves and the normal functioning of the affected organ resumes due to the death of bacteria.

Antibiotic or not?

The drug has antibacterial and bactericidal action. HP is not an antibiotic, because. different from this group of drugs chemical composition and does not have similar means of natural origin.

Release form

It is produced in the form of tablets that have an orange tint. 1 package contains 10 pcs.

Pharmacological group

Antibacterial drug of the fluoroquinolone group.

Pharmacological properties of Nolicin

There is a broad effect of the drug.

Pharmacodynamics

The antimicrobial effect lasts up to 12 hours.

To have a therapeutic effect, the components in the composition of the drug act on the DNA of bacteria, destroying it. A broken DNA chain leads to the death of pathogenic bacteria.

Various types of trace elements are sensitive to the drug.

Pharmacokinetics

The active substance is absorbed quickly, but not completely. Absorption from the gastrointestinal tract reaches 20-40%. The maximum concentration is observed after a few hours (1-2 depending on the individual characteristics of the organism). If you take a tablet during a meal, the absorption time will increase.

Penetrates into internal organs and pelvic tissue. Has the ability to stand out with milk. Penetrates through the placental barrier.

The process of metabolism occurs in the liver in small quantities.

The half-life is 3-4 hours. It is excreted by the kidneys within 1 day from the moment of administration. About 30% of the dose is excreted in the bile.

Indications for use

Effective for the following diagnoses:

• acute or chronic urinary tract infections (eg, urethritis, cystitis, pyelonephritis);
• genital infections (cervicitis, endometritis, chronic bacterial prostatitis);
• gonorrhea in uncomplicated form;
• bacterial gastroenteritis (salmonellosis, shigellosis);
• prevention of recurrence of urinary tract infections;
• prevention of sepsis in patients with neutropenia;
• prevention of diarrhea in people who travel a lot.

With cystitis

Used for therapeutic purposes. It can be prescribed as a measure for the prevention of recurrent conditions. Efficiency differs in preventing the development of complications and the development of a chronic form. More drug for the treatment of cystitis is suitable for men. Women with cystitis are also prescribed candles so that thrush does not occur as a concomitant disease.

With urethritis

With urethritis, it relieves discomfort, pain and pain in the urethra. Symptoms of the disease disappear after 3-5 days of treatment, depending on neglect.

With pyelonephritis

Prescribed for exacerbation chronic disease and to prevent exacerbations.

With inflammation of the kidneys

In the inflammatory process, it relieves swelling, pain, discomfort during urination. Helps relieve symptoms of kidney stones.

How to take Nolicin?

The average dose is 1 tablet 2 times a day. With the following diagnoses, it is recommended to adhere to the indicated dosages:

1. Chronic prostatitis - 400 mg 2 times a day. Continue treatment up to 6 weeks. In the absence of results, therapy is prolonged or the drug is replaced.
2. Gonorrhea in uncomplicated form - 2-4 tablets once or 400 mg 2 times a day for a week. The course of treatment depends on concomitant diseases and other drugs.
3. Shigellosis, salmonellosis and other bacterial gastroenteritis - the duration of treatment should not exceed 5 days. Take 1 tablet 2 times a day.
4. For the prevention of diarrhea in travelers, use 1 tablet daily. Take the first dose 1 day before departure and continue for 2 more days after the end of the trip. It is not recommended to take the drug for more than 21 days.
5. Sepsis in neutropenic patients. Reception of drugs is carried out within 2 months.
6. Uncomplicated cystitis - 3-5 days, 1 tablet 2 times a day.

For the prevention of urinary tract infections, the drug is used for a long time (from 6 months). Take 1 tablet at night.

Before meals or after?

For better absorption, tablets are taken 1-2 hours after a meal, washed down with plenty of liquid.

How many days to drink?

LS is taken for 10-14 days. In some cases, therapy is extended at the discretion of the doctor.

How long does Nolicin work?

Symptoms of the disease disappear within 2-5 days after the start of treatment. Complete recovery of the patient is observed on the 10-14th day of treatment with simple forms of diseases.

Contraindications

• deficiency of glucose-6-phosphate dehydrogenase;
• lactation or pregnancy;
• children's age up to 18 years;
• individual intolerance to the components in the composition of the drug.

Use under medical supervision if:

• disorders of blood circulation in the brain;
• epilepsy;
• vascular disorders of the brain;
• kidney or liver failure.

Side effects

Taking the drug can affect the work of many organs:

1. Digestive system: loss of appetite, bitter taste in the mouth, nausea, vomiting, abdominal pain, diarrhea, increased activity of liver transaminases.
2. Urinary system: bleeding in the urethra, increased levels of urea and creatinine, dysuria, polyuria.
3. CNS: dizziness, headache, fainting, insomnia, hallucinations. Elderly patients experience fatigue, sleep disturbances, anxiety, irritation, an inexplicable feeling of fear, depression, and tinnitus.
4. CCC: decreased blood pressure, palpitations.
5. Musculoskeletal system: tendon ruptures, arthralgia.
6. Hematopoiesis: leukopenia, eosinophilia.
7. Allergic manifestations: rash, itching, urticaria, swelling.

Overdose

If you experience excessive sweating, dizziness, drowsiness, seizures, consult a doctor. Symptoms are treated by gastric lavage in a stationary mode.

special instructions

During the treatment period, the water balance should be monitored. Patients should get plenty of fluids, avoid sunbathing and tanning beds.

With discomfort in the tendons, the abolition of drugs is required. To avoid this, it is necessary to suspend sports training and not overload the body physically.

There is a risk of developing an allergy to the shell dye.

Use during pregnancy and breastfeeding

Application in childhood

Not intended for the treatment of children under 18 years of age.

For impaired renal function

Dose adjustment is required depending on the diagnosis. Daily rate should be less than in patients with healthy kidneys.

For impaired liver function

Reception is carried out under the supervision of a doctor and with normal indicators and the state of the liver during the treatment period.

Alcohol compatibility

When using drugs with alcohol-containing drinks, the risk of developing adverse reactions increases, and the level of effectiveness of the drug decreases.

drug interaction

Mutual influence with the following drugs is noted:

1. The effectiveness of nitrofurans decreases with simultaneous use.
2. The action of Cyclosporine and Warfarin is enhanced.
3. Preparations containing zinc, iron or magnesium make absorption slow. Therefore, the interval between doses should be at least 2 hours.
4. GCS increases the risk of tendon rupture.

Analogues

Cheaper analogues of drugs:

1. Palin.
2. Furamag.
3. Monural.
4. Furadonin.
5. Norbaktin.
6. Kanefron.

Terms and conditions of storage

The shelf life is 5 years, subject to storage conditions (temperature regime not more than + 25ºС, a place inaccessible to children).